Swiss scientists have succeeded in visualising the process of crystal nucleation that precedes crystallisation, considered invisible until now.
The University of Geneva (UNIGE) in Switzerland said in a statement on 20th April: “At the interface between chemistry and physics, the process of crystallization is omnipresent in nature and industry. It is the basis for the formation of snowflakes but also of certain active ingredients used in pharmacology.
“For the phenomenon to occur for a given substance, it must first go through a stage so-called nucleation, during which the molecules organize themselves and create the optimal conditions for the formation of crystals.
“While it has been difficult to observe this pre-nucleation dynamics, this key process has now been revealed by the work of a research team from the University of Geneva.”
UNIGE stated: “The scientists have succeeded in visualizing this process spectroscopically in real time and on a micrometric scale, paving the way to the design of safer and more stable active substances.”
“Crystallization is a chemical and physical process used in many fields, from the pharmaceutical industry to food processing. It is used to isolate a gaseous or liquid substance in the form of crystals.
“However, this phenomenon is not unique to industry; it is ubiquitous in nature and can be seen, for example, in snowflakes, coral or kidney stones.
“For crystals to form from substances, they must first go through a crucial stage called nucleation. It is during this first phase that the molecules begin to arrange themselves to form ‘nucleus’, stable clusters of molecules, which leads to the development and growth of crystal.
This process occurs stochastically, meaning it is not predictable when and where a nucleus form.
Takuji Adachi, UNIGE assistant professor in the Department of Physical Chemistry, said: “Until now, scientists have been struggling to visualize this first stage at the molecular level. The microscopic picture of crystal nucleation has been under intense debate.
“Recent studies suggest that molecules seem to form some disordered organization before the formation of ‘nuclei’. Then how does the crystalline order emerge from them? That is a big question!”
Researcher and co-first author of the study Johanna Brazard said: “We have succeeded in demonstrating and visualizing the organization and formation of molecular aggregates that precede crystallization.
Co-first author Oscar Urquidi said: “We used lasers to highlight the molecular structure during the nucleation but also to induce the nucleation phenomenon and thus be able to observe it and record its spectral imprint”
The model substance chosen to conduct these experiments was glycine dissolved in water.
Takuji Adachi stated: “Our work has revealed a stage of crystallization that was previously invisible.
“Visualizing more precisely and better understanding what is happening at the molecular level is very useful for directing certain manipulations more effectively.”
UNIGE said the discovery “could make it easier to obtain purer and more stable crystal structures for certain substances used in the design of many drugs or materials”.
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